Crystallization-Induced Diastereoisomer Transformation of Dihydroartemisinic Aldehyde with the Betti Base
نویسندگان
چکیده
منابع مشابه
An Efficient Chemoenzymatic Synthesis of Dihydroartemisinic Aldehyde
Artemisinin from the plant Artemisia annua is the most potent pharmaceutical for the treatment of malaria. In the plant, the sesquiterpene cyclase amorphadiene synthase, a cytochrome-dependent CYP450, and an aldehyde reductase convert farnesyl diphosphate (FDP) into dihydroartemisinic aldehyde (DHAAl), which is a key intermediate in the biosynthesis of artemisinin and a semisynthetic precursor ...
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ژورنال
عنوان ژورنال: Organic Process Research & Development
سال: 2020
ISSN: 1083-6160,1520-586X
DOI: 10.1021/acs.oprd.9b00481